Nitric oxide in primary ciliary dyskinesia.

Nasal nitric oxide is low early in life: case study of two infants with primary ciliary dyskinesia.

Nasal nitric oxide levels are low in patients with primary ciliary dyskinesia, but it is not known whether this defect is already present in the first months of life. The current authors measured nasal nitric oxide in two infants with situs inversus and primary ciliary dyskinesia, diagnosed by electron microscopy at 4 and 6 months of age, and in five healthy control infants. Nasal nitric oxide ...

Primary Ciliary Dyskinesia: Ready for Quality of Life Assessment.

Primary ciliary dyskinesia (PCD) is a chronic, inherited disease characterized by ciliary dysfunction leading to defects in mucociliary clearance, thus causing upper and lower respiratory problems such as sinusitis and bronchiectasis as well as infertility. Diagnostic workup includes a combination of different techniques such as nasal nitric oxide measurement, high-speed video microscopy analys...

Exhaled nitric oxide in contrasting population samples of Finnish and Russian Karelia.

1 Bush A, Chodhari R, Collins N, et al. Primary ciliary dyskinesia: current state of the art. Arch Dis Child 2007; 92: 1136–1140. 2 Lie H, Ferkol T. Primary ciliary dyskinesia: recent advances in pathogenesis, diagnosis and treatment. Drugs 2007; 67: 1883–1892. 3 Pifferi M, Cangiotti AM, Ragazzo V, et al. Primary ciliary dyskinesia: diagnosis in children with inconclusive ultrastructural evalua...

Primary ciliary dyskinesia: mechanisms and management

Primary ciliary dyskinesia is a genetically heterogeneous disorder of motile cilia that is predominantly inherited in an autosomal-recessive fashion. It is associated with abnormal ciliary structure and/or function leading to chronic upper and lower respiratory tract infections, male infertility, and situs inversus. The estimated prevalence of primary ciliary dyskinesia is approximately one in ...

Author's response to reviews Title:Validation of a portable nitric oxide analyser for screening in primary ciliary dyskinesia Authors:

Effect of L-arginine infusion on airway NO in cystic fibrosis and primary ciliary dyskinesia syndrome.

Airway nitric oxide concentrations in patients with cystic fibrosis or primary ciliary dyskinesia syndrome have been shown to be lower than in healthy subjects. Decreased NO concentrations may contribute to impaired ciliary clearance, respiratory tract infections, or obstructive lung disease in these conditions. Nasal and exhaled NO concentrations were compared before and after infusion of 500 ...